Welcome to the Charest Lab!
In the laboratory of Dr. Pascale Charest at the University of Arizona, we study how cells migrate in response to external chemical cues (chemoattractants), a process (chemotaxis) that is important to normal physiology and that is also implicated in the onset and progression of diseases such as cancer metastasis. Metastasis, the migration of cancer cells away from the primary tumor to other parts of the body, is by far the major cause of death from cancer. Yet, most anti-cancer drugs inhibit only cancer cell proliferation. One main reason for the lack of efficient anti-metastasis therapy is our lack of understanding of what promotes tumor cell migration and invasion. Our goal is to identify key, conserved intracellular signaling pathways and molecular mechanisms that control cell migration to guide the development of therapeutic strategies preventing the spread of cancer. For this, we work with the model organism Dictyostelium discoideum as well as normal and transformed human cells, and we use collaborative, interdisciplinary approaches that include cellular, molecular, biochemical, biophysical, omics, and computational methods.
Charest Lab News
March 2025
We are welcoming two new graduate students to the Charest lab: Maniza Muni (Dep. Chemistry & Biochemistry; Biological Chemistry Program, Biochemistry track) and Meena Khan (Dep. Molecular and Cellular Biology; Biochemistry, Molecular & Cellular Biology program). Both Maniza and Meena will conduct research to understand the role and regulation of chemoattractant receptor dynamics in chemotaxis.
We are welcoming two new graduate students to the Charest lab: Maniza Muni (Dep. Chemistry & Biochemistry; Biological Chemistry Program, Biochemistry track) and Meena Khan (Dep. Molecular and Cellular Biology; Biochemistry, Molecular & Cellular Biology program). Both Maniza and Meena will conduct research to understand the role and regulation of chemoattractant receptor dynamics in chemotaxis.
|
November 2024
Undergraduate student and MARC scholar Caleb Konecek attended and presented his research work at the Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS), and was awarded a poster presentation award! Well done Caleb! |
Caleb at his poster at the ABRCMS, Pittsburgh, Nov 2024
|
August 2024
The Charest lab receives new funding from the National Science Foundation to study the role of receptor dynamics in eukaryotic chemotaxis, in collaboration with Wouter-Jan Rappel at UCSD. We are excited to start working on this research project!
The Charest lab receives new funding from the National Science Foundation to study the role of receptor dynamics in eukaryotic chemotaxis, in collaboration with Wouter-Jan Rappel at UCSD. We are excited to start working on this research project!
|
June-July 2024
This summer we hosted one high school KEYS intern, Katie Jennings. Katie worked with undergraduate student and Beckman Scholar Douglas Swango, a former KEYS intern himself. Way to give back! In addition, undergraduate student Caleb Konecek was awarded a Dr Thomas M. and Candace C. Grogan Scholarship from the Department of Chemistry and Biochemistry. Congratulations! |
Dr Charest, Katie, and Douglas at Katie's poster presentation on July 19.
|
May 2024
Former graduate student Stephen Smith's article has been published in the Journal of Biological Chemistry. Great work Stephen, congratulations! And also thank you to the contributing authors: Tariq Islam, Shon Alimukhamedov, and Ethan Weiss.
Congratulations to our lab graduates: Elizabeth (Liz) Harper (Biochemistry BSc), Natalya Stanisic (Molecular & Cellular Biology BSc), and Genesis Cahigas (Biochemistry PhD)! Liz is staying with us one more year to complete her Accelerated Master's program in Biochemistry, Natalya is applying for Medical School, and Genesis is applying for work in industry. We celebrated their graduations and the end of the semester with a bowling party!
April 2024
Graduate student Genesis Cahigas successfully defended his dissertation, congratulations Dr. Cahigas!
Former graduate student Stephen Smith's article has been published in the Journal of Biological Chemistry. Great work Stephen, congratulations! And also thank you to the contributing authors: Tariq Islam, Shon Alimukhamedov, and Ethan Weiss.
Congratulations to our lab graduates: Elizabeth (Liz) Harper (Biochemistry BSc), Natalya Stanisic (Molecular & Cellular Biology BSc), and Genesis Cahigas (Biochemistry PhD)! Liz is staying with us one more year to complete her Accelerated Master's program in Biochemistry, Natalya is applying for Medical School, and Genesis is applying for work in industry. We celebrated their graduations and the end of the semester with a bowling party!
April 2024
Graduate student Genesis Cahigas successfully defended his dissertation, congratulations Dr. Cahigas!
Charest lab May 2024. Left to right, back row: Douglas Swango, Tariq Islam, Natalya Stanisic, Isiah Toth, Caleb Konecek. Front row: Mollie Wiegand, Agata Orlinski, Elizabeth Harper, Pascale Charest, Genesis Cahigas. Missing from photo: Helena Woroniecka, Kate Santiago, Megan Dowd, Shruthi Sadhasivam, Olivia Hajdys.
